LongevityMap Gene

Gene details

HGNC symbol
F7 
Aliases
SPCA 
Common name
coagulation factor VII 
Description
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
Cytogenetic Location
13q34
UCSC Genome Browser
View 13q34 on the UCSC genome browser
OMIM
613878
Ensembl
ENSG00000057593
UniProt/Swiss-Prot
B4DPM2_HUMAN
Entrez Gene
2155
UniGene
36989
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
F7 (1 of many)
Danio rerio
f7
Mus musculus
F7
Rattus norvegicus
F7

Studies (5)

Significant/Non-significant: 1/4

Study 1

Longevity Association
Non-significant
Population
Italian
Study Design
The R353Q substitution polymorphism in exon 8 was examined in 124 healthy individuals over 100 years of age and 130 young, healthy individuals
Conclusions
No significant differences relative to longevity were found
Indentifier
R353Q
Reference

    Study 2

    Longevity Association
    Non-significant
    Population
    Danish
    Study Design
    The R353Q substitution, intron 7 (37bp)n, and -323ins10 polymorphisms were examined in 187 centenarians and 201 healthy controls, aged 20-64 years (mean age 42 years).
    Conclusions
    The genotype frequencies in the centenarians and in the controls were similar
    Indentifier
    R353Q
    Reference

      Study 3

      Longevity Association
      Non-significant
      Population
      Danish
      Study Design
      Polymorphisms were examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years)
      Conclusions
      No association with longevity was found
      Indentifier
      F7
      Reference

        Study 4

        Longevity Association
        Non-significant
        Population
        Ashkenazi Jewish (Jerusalem)
        Study Design
        Arg/Gln R353Q SNP was examined in 224 older (>75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years)
        Conclusions
        There was a decrease in the percentage of the A allele in older Ashkenazi male subjects and a corresponding marked decrease (9.7-2.1%) in the percentage of AA homozygotes, though this was not significant after correcting for multiple testing
        Indentifier
        Arg/Gln R353Q
        Reference

          Study 5

          Longevity Association
          Significant
          Population
          Danish
          Study Design
          Blood coagulation factor VII (FVII) R/Q353 and FVII-323ins10 SNPs were examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years)
          Conclusions
          R/Q353 and FVII-323ins10 manifest significant influences on survival in males, with reduced hazards of death for carriers of the Q353 allele and the FVII-323P10 allele
          Indentifier
          R/Q353
          Reference