LongevityMap Gene

Gene details

HGNC symbol: F7
Aliases: SPCA
Common name: coagulation factor VII
Description: This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
Cytogenetic Location: 13q34
UCSC Genome Browser: View 13q34 on the UCSC genome browser
OMIM: 613878
Ensembl: ENSG00000057593
UniProt/Swiss-Prot: B4DPM2_HUMAN
Entrez Gene: 2155
UniGene: 36989
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: F7 (1 of many)
Danio rerio: f7
Mus musculus: F7
Rattus norvegicus: F7

Studies (5)

Significant/Non-significant: 1/4

Study 1

Longevity Association

Non-significant

Population

Study Design

The R353Q substitution polymorphism in exon 8 was examined in 124 healthy individuals over 100 years of age and 130 young, healthy individuals

Conclusions

No significant differences relative to longevity were found

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

The R353Q substitution, intron 7 (37bp)n, and -323ins10 polymorphisms were examined in 187 centenarians and 201 healthy controls, aged 20-64 years (mean age 42 years).

Conclusions

The genotype frequencies in the centenarians and in the controls were similar

Indentifier

Reference

Study 3

Longevity Association

Non-significant

Population

Study Design

Polymorphisms were examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years)

Conclusions

No association with longevity was found

Indentifier

Reference

Study 4

Longevity Association

Non-significant

Population

Ashkenazi Jewish (Jerusalem)

Study Design

Arg/Gln R353Q SNP was examined in 224 older (>75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years)

Conclusions

There was a decrease in the percentage of the A allele in older Ashkenazi male subjects and a corresponding marked decrease (9.7-2.1%) in the percentage of AA homozygotes, though this was not significant after correcting for multiple testing

Indentifier

Reference

Study 5

Longevity Association

Population

Study Design

Blood coagulation factor VII (FVII) R/Q353 and FVII-323ins10 SNPs were examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years)

Conclusions

R/Q353 and FVII-323ins10 manifest significant influences on survival in males, with reduced hazards of death for carriers of the Q353 allele and the FVII-323P10 allele

Indentifier

Reference