LongevityMap Gene

Gene details

HGNC symbol
EGFR 
Aliases
ERBB; HER1; mENA; ERBB1; PIG61; NISBD2 
Common name
epidermal growth factor receptor 
Description
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
Cytogenetic Location
7p11.2
UCSC Genome Browser
View 7p11.2 on the UCSC genome browser
OMIM
131550
Ensembl
ENSG00000146648
UniProt/Swiss-Prot
B7Z2I3_HUMAN
Entrez Gene
1956
UniGene
488293
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
egfra
Drosophila melanogaster
Egfr
Mus musculus
Egfr
Rattus norvegicus
Egfr

In other databases

GenAge human genes
  • This gene is present as EGFR

Studies (1)

Significant/Non-significant: 1/0

Longevity Association
Significant
Population
Korean
Study Design
463 biomarkers in 176 diesase associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
Conclusions
EGFR was associated with longevity (P = 0.003) after correcting for multiple hypothesis testing
Indentifier
rs2072454
Reference