LongevityMap Gene
Gene details
- HGNC symbol
- EBF3
- Aliases
- COE3; OE-2; EBF-3; HADDS; O/E-2
- Common name
- early B-cell factor 3
- Description
- This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011]
- Cytogenetic Location
- 10q26.3
- UCSC Genome Browser
- View 10q26.3 on the UCSC genome browser
- OMIM
- 607407
- Ensembl
- ENSG00000108001
- UniProt/Swiss-Prot
- COE3_HUMAN
- Entrez Gene
- 253738
- UniGene
- 591374
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- unc-3
- Danio rerio
- ebf3a
- Drosophila melanogaster
- kn
- Mus musculus
- Ebf3
- Rattus norvegicus
- Ebf3
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs4751140
- Reference