LongevityMap Gene
Gene details
- HGNC symbol
- DOK6
- Aliases
- DOK5L; HsT3226
- Common name
- docking protein 6
- Description
- DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008]
- Cytogenetic Location
- 18q22.2
- UCSC Genome Browser
- View 18q22.2 on the UCSC genome browser
- OMIM
- 611402
- Ensembl
- ENSG00000206052
- UniProt/Swiss-Prot
- DOK6_HUMAN
- Entrez Gene
- 220164
- UniGene
- 278285
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs10401068
- Reference