LongevityMap Gene
Gene details
- HGNC symbol
- DOCK2
- Aliases
- IMD40
- Common name
- dedicator of cytokinesis 2
- Description
- The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
- Cytogenetic Location
- 5q35.1
- UCSC Genome Browser
- View 5q35.1 on the UCSC genome browser
- OMIM
- 603122
- Ensembl
- ENSG00000134516
- UniProt/Swiss-Prot
- DOCK2_HUMAN
- Entrez Gene
- 1794
- UniGene
- 586174
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- ced-5
- Drosophila melanogaster
- mbc
- Mus musculus
- Dock2
- Rattus norvegicus
- Dock2
- Saccharomyces cerevisiae
- 851141
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as YLR422W
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs262883
- Reference