LongevityMap Gene

Gene details

HGNC symbol: DOCK2
Aliases: IMD40
Common name: dedicator of cytokinesis 2
Description: The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
Cytogenetic Location: 5q35.1
UCSC Genome Browser: View 5q35.1 on the UCSC genome browser
OMIM: 603122
Ensembl: ENSG00000134516
UniProt/Swiss-Prot: DOCK2_HUMAN
Entrez Gene: 1794
UniGene: 586174
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: ced-5
Drosophila melanogaster: mbc
Mus musculus: Dock2
Rattus norvegicus: Dock2
Saccharomyces cerevisiae: 851141

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as YLR422W

Studies (1)

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

Reference