LongevityMap Gene
Gene details
- HGNC symbol
- DIRAS2
- Aliases
- Di-Ras2
- Common name
- DIRAS family GTPase 2
- Description
- DIRAS2 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]
- Cytogenetic Location
- 9q22.2
- UCSC Genome Browser
- View 9q22.2 on the UCSC genome browser
- OMIM
- 607863
- Ensembl
- ENSG00000165023
- UniProt/Swiss-Prot
- DIRA2_HUMAN
- Entrez Gene
- 54769
- UniGene
- 165636
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- DIRAS2
- Drosophila melanogaster
- CG8500
- Mus musculus
- Diras2
- Rattus norvegicus
- Diras2
- Saccharomyces cerevisiae
- RSR1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
- Indentifier
- rs690232
- Reference