LongevityMap Gene
Gene details
- HGNC symbol
- DCPS
- Aliases
- ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015
- Common name
- decapping enzyme, scavenger
- Description
- This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]
- Cytogenetic Location
- 11q24.2
- UCSC Genome Browser
- View 11q24.2 on the UCSC genome browser
- OMIM
- 610534
- Ensembl
- ENSG00000110063
- UniProt/Swiss-Prot
- DCPS_HUMAN
- Entrez Gene
- 28960
- UniGene
- 504249
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- dcs-1
- Danio rerio
- dcps
- Drosophila melanogaster
- CG2091
- Mus musculus
- Dcps
- Rattus norvegicus
- Dcps
- Saccharomyces cerevisiae
- DCS2
- Saccharomyces cerevisiae
- DCS1
- Schizosaccharomyces pombe
- nhm1
In other databases
- CellAge gene expression
- This gene is present as DCPS
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs651922
- Reference