LongevityMap Gene

Gene details

HGNC symbol: DCPS
Aliases: ARS; DCS1; HSL1; HINT5; HINT-5; HSPC015
Common name: decapping enzyme, scavenger
Description: This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5′ mRNA cap structure, which appear in the 3′ → 5′ mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover. [provided by RefSeq, Apr 2017]
Cytogenetic Location: 11q24.2
UCSC Genome Browser: View 11q24.2 on the UCSC genome browser
OMIM: 610534
Ensembl: ENSG00000110063
UniProt/Swiss-Prot: DCPS_HUMAN
Entrez Gene: 28960
UniGene: 504249
1000 Genomes: 1000 Genomes

CellAge gene expression

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs651922

Reference