LongevityMap Gene
Gene details
- HGNC symbol
- DCLK1
- Aliases
- CL1; DCLK; CLICK1; DCDC3A; DCAMKL1
- Common name
- doublecortin like kinase 1
- Description
- This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]
- Cytogenetic Location
- 13q13.3
- UCSC Genome Browser
- View 13q13.3 on the UCSC genome browser
- OMIM
- 604742
- Ensembl
- ENSG00000133083
- UniProt/Swiss-Prot
- B7Z5K4_HUMAN
- Entrez Gene
- 9201
- UniGene
- 507755
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- zyg-8
- Danio rerio
- dclk1a
- Drosophila melanogaster
- CG17528
- Mus musculus
- Dclk1
- Rattus norvegicus
- Dclk1
- Saccharomyces cerevisiae
- DUN1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as DUN1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
- Conclusions
- A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
- Indentifier
- rs9315385
- Reference