LongevityMap Gene
Gene details
- HGNC symbol
- CYTH3
- Aliases
- GRP1; ARNO3; PSCD3; cytohesin-3
- Common name
- cytohesin 3
- Description
- This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 7p22.1
- UCSC Genome Browser
- View 7p22.1 on the UCSC genome browser
- OMIM
- 605081
- Ensembl
- ENSG00000008256
- UniProt/Swiss-Prot
- CYH3_HUMAN
- Entrez Gene
- 9265
- UniGene
- 487479
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- grp-1
- Danio rerio
- cyth3a
- Danio rerio
- si:ch211-189a21.1
- Danio rerio
- cyth3b
- Drosophila melanogaster
- step
- Mus musculus
- Cyth3
- Rattus norvegicus
- Cyth3
- Saccharomyces cerevisiae
- SEC7
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs7803143
- Reference