LongevityMap Gene
Gene details
- HGNC symbol
- CYP2C9
- Aliases
- CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
- Common name
- cytochrome P450 family 2 subfamily C member 9
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 10q23.33
- UCSC Genome Browser
- View 10q23.33 on the UCSC genome browser
- OMIM
- 601130
- Ensembl
- ENSG00000138109
- UniProt/Swiss-Prot
- CP2C9_HUMAN
- Entrez Gene
- 1559
- UniGene
- 282624
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- cyp2y3
- Danio rerio
- si:zfos-411a11.2
- Mus musculus
- Cyp2c50
- Mus musculus
- Cyp2c54
- Mus musculus
- Cyp2c67
- Mus musculus
- Cyp2c69
- Mus musculus
- Cyp2c66
- Mus musculus
- Cyp2c68
- Mus musculus
- Cyp2c65
- Mus musculus
- Cyp2c38
- Mus musculus
- Cyp2c37
- Mus musculus
- Cyp2c29
- Mus musculus
- Cyp2c39
- Mus musculus
- Cyp2c40
- Rattus norvegicus
- Cyp2c7
- Rattus norvegicus
- LOC100361547
- Rattus norvegicus
- AABR07004539.1
- Rattus norvegicus
- Cyp2c12
- Rattus norvegicus
- Cyp2c6v1
- Rattus norvegicus
- Cyp2c13
- Rattus norvegicus
- LOC100361547
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genotyping of 56 single nucleotide polymorphisms located in the CYP2C gene family was performed for 1384 unrelated long-lived individuals (age range: 95-109 years, mean: 98.8 years), including 616 centenarians (mean age: 101.3 years), and 945 younger controls (age range: 60-75 years, mean: 66.9 years). The gender ratio was 73% females versus 27% males.
- Conclusions
- None of the tested single nucleotide polymorphisms showed a significant association with the longevity phenotype at the allele, genotype, or haplotype level
- Indentifier
- rs2475377
- Reference