LongevityMap Gene
Gene details
- HGNC symbol
- CXCL8
- Aliases
- IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
- Common name
- C-X-C motif chemokine ligand 8
- Description
- The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 4q13.3
- UCSC Genome Browser
- View 4q13.3 on the UCSC genome browser
- OMIM
- 146930
- Ensembl
- ENSG00000169429
- UniProt/Swiss-Prot
- A0A024RDA5_HUMAN
- Entrez Gene
- 3576
- UniGene
- 624
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- CXCL8
Studies (2)
Significant/Non-significant: 0/2
Study 1
- Longevity Association
- Non-significant
- Population
- Irish
- Study Design
- 100 control samples (59% female and 41% male) and 93 aged consecutive samples (70% female, 30% male with an age range of 80-97 years) were analyzed for Intron 1 A/T SNP
- Conclusions
- No significant differences were observed in centenarians and controls
- Indentifier
- IL8
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs4073
- Reference