LongevityMap Gene

Gene details

HGNC symbol: CXCL8
Aliases: IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
Common name: C-X-C motif chemokine ligand 8
Description: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 4q13.3
UCSC Genome Browser: View 4q13.3 on the UCSC genome browser
OMIM: 146930
Ensembl: ENSG00000169429
UniProt/Swiss-Prot: A0A024RDA5_HUMAN
Entrez Gene: 3576
UniGene: 624
1000 Genomes: 1000 Genomes

Significant/Non-significant: 0/2

Longevity Association

Non-significant

Population

Irish

Study Design

Conclusions

Indentifier

IL8

Reference

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier