LongevityMap Gene
Gene details
- HGNC symbol
- CNTN5
- Aliases
- NB-2; HNB-2s
- Common name
- contactin 5
- Description
- The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
- Cytogenetic Location
- 11q22.1
- UCSC Genome Browser
- View 11q22.1 on the UCSC genome browser
- OMIM
- 607219
- Ensembl
- ENSG00000149972
- UniProt/Swiss-Prot
- CNTN5_HUMAN
- Entrez Gene
- 53942
- UniGene
- 656783
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (2)
Significant/Non-significant: 0/2
Study 1
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study for longevity-related traits in up to 1345 Framingham Study participants from 330 families; 713 participants achieved age 65 years or greater. A total of 79 potential candidate genes and regions associated with longevity were also studied.
- Conclusions
- Although no genome-wide associations were significant, mutiple SNPs and genes had suggestive associations with both age at death and morbidity-free survival at age 65 years
- Indentifier
- rs655883
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs7103504
- Reference