LongevityMap Gene
Gene details
- HGNC symbol
- CNR1
- Aliases
- CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
- Common name
- cannabinoid receptor 1
- Description
- This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
- Cytogenetic Location
- 6q15
- UCSC Genome Browser
- View 6q15 on the UCSC genome browser
- OMIM
- 114610
- Ensembl
- ENSG00000118432
- UniProt/Swiss-Prot
- CNR1_HUMAN
- Entrez Gene
- 1268
- UniGene
- 75110
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as CNR1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs6454676
- Reference