LongevityMap Gene

Gene details

HGNC symbol
CNR1 
Aliases
CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5 
Common name
cannabinoid receptor 1 
Description
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Cytogenetic Location
6q15
UCSC Genome Browser
View 6q15 on the UCSC genome browser
OMIM
114610
Ensembl
ENSG00000118432
UniProt/Swiss-Prot
CNR1_HUMAN
Entrez Gene
1268
UniGene
75110
1000 Genomes
1000 Genomes

Homologs in model organisms

Danio rerio
cnr1
Mus musculus
Cnr1
Rattus norvegicus
Cnr1

In other databases

GenAge human genes
  • This gene is present as CNR1

Studies (1)

Significant/Non-significant: 0/1

Longevity Association
Non-significant
Population
American, English, Irish
Study Design
10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
Conclusions
Some signals were at best tentative but may merit study in larger sample sets
Indentifier
rs6454676
Reference