LongevityMap Gene
Gene details
- HGNC symbol
- CHST4
- Aliases
- GST3; LSST; GlcNAc6ST2; HECGLCNAC6ST
- Common name
- carbohydrate sulfotransferase 4
- Description
- This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
- Cytogenetic Location
- 16q22.2
- UCSC Genome Browser
- View 16q22.2 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000140835
- UniProt/Swiss-Prot
- CHST4_HUMAN
- Entrez Gene
- 10164
- UniGene
- 251383
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- CHST6
- Drosophila melanogaster
- CG31637
- Drosophila melanogaster
- CG9550
- Mus musculus
- Chst4
- Rattus norvegicus
- Chst4
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
- Indentifier
- rs4149497
- Reference