LongevityMap Gene

Gene details

HGNC symbol: CHST11
Aliases: C4ST; C4ST1; C4ST-1; HSA269537
Common name: carbohydrate sulfotransferase 11
Description: The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Cytogenetic Location: 12q23.3
UCSC Genome Browser: View 12q23.3 on the UCSC genome browser
OMIM: 610128
Ensembl: ENSG00000171310
UniProt/Swiss-Prot: A0A024RBL0_HUMAN
Entrez Gene: 50515
UniGene: 17569
1000 Genomes: 1000 Genomes

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

rs1922263

Reference