LongevityMap Gene
Gene details
- HGNC symbol
- CFLAR
- Aliases
- CASH; FLIP; MRIT; CLARP; FLAME; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1
- Common name
- CASP8 and FADD like apoptosis regulator
- Description
- The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
- Cytogenetic Location
- 2q33.1
- UCSC Genome Browser
- View 2q33.1 on the UCSC genome browser
- OMIM
- 603599
- Ensembl
- ENSG00000003402
- UniProt/Swiss-Prot
- A0A024R3Y3_HUMAN
- Entrez Gene
- 8837
- UniGene
- 390736
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Genome-wide association study on 410 long-living individuals (age range, 90–109 years) and 553 young control individuals (age range, 18–48 years) using 318,237 SNPs. An independent population with 116 long-lived individuals and 160 controls was used for replication purposes.
- Conclusions
- A total of 67 SNPs were identified with an indication of potentially being associated with longevity (p < 1 × 10−4), though 66 were not further validated
- Indentifier
- rs7583529
- Reference