LongevityMap Gene

Gene details

HGNC symbol: CETP
Aliases: BPIFF; HDLCQ10
Common name: cholesteryl ester transfer protein
Description: The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Cytogenetic Location: 16q13
UCSC Genome Browser: View 16q13 on the UCSC genome browser
OMIM: 118470
Ensembl: ENSG00000087237
UniProt/Swiss-Prot: A0A0S2Z3F6_HUMAN
Entrez Gene: 1071
UniGene: 89538
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: cetp

In other databases

GenAge human genes

This gene is present as CETP

Studies (9)

Significant/Non-significant: 4/5

Study 1

Longevity Association

Non-significant

Population

Study Design

Polymorphisms (mutations in intron 14 and exon 15, and Taq1B) were examined in 256 centenarians and 190 healthy younger controls (22-65 years old)

Conclusions

The allelic frequencies did not differ between the two groups

Indentifier

Reference

Study 2

Longevity Association

Population

Ashkenazi Jewish

Study Design

The I405V polymorphism distribution was examined in 213 Ashkenazi Jews with exceptional longevity (mean [SD] age, 98.2 [5.3] years), their offspring (n = 216; mean [SD] age, 68.3 [6.7] years) and in an age-matched control group of Ashkenazi Jews (n = 258) plus in participants from the Framingham Offspring Study (n = 589)

Conclusions

Probands with exceptional longevity showed an increased frequency of homozygosity for the 405 valine allele (VV genotype) compared with controls

Indentifier

Reference

Study 3

Longevity Association

Non-significant

Population

Study Design

The I405V polymorphism was examined in 175 Italian centenarians and, as a control group, 189 sex-matched healthy individuals

Conclusions

No association with longevity was found

Indentifier

Reference

Study 4

Longevity Association

Population

Ashkenazi Jewish

Study Design

Case-control study for phenotype and genotype of exceptional longevity in a genetically homogenous population (Ashkenazi Jews, 80% female), and their offspring (320 subjects, 55% female). An age-matched control group of Ashkenazi Jews (n = 258) was used as control group.

Conclusions

A functional CETP variant contributed to the better health performance and thus exceptional longevity (P < 0.05).

Indentifier

Reference

Study 5

Longevity Association

Non-significant

Population

Study Design

The distribution of CETP*V and APOE*4 were analyzed in 372 oldest-old women (aged 80-109) and 340 controls (aged 20-58).

Conclusions

No contribution of CETP I405V to longevity was found.

Indentifier

Reference

Study 6

Longevity Association: Non-significant
Population: Greek
Study Design: 307 individuals (190 nonagenarians, 12 centenarians and 105 middle-aged controls) were genotyped for ACE, NFkB, and CETP genetic variants
Conclusions: No significant difference were found between case group and control group for NFkB and CETP
Indentifier

Study 7

Longevity Association: Significant
Population: Danish, German, Dutch
Study Design: 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
Conclusions: The minor allele frequency of rs9923854 in CETP was significantly associated with longevity. Haplotype case–control comparisons identified two haplotypes associated with longevity. Gene-based analysis confirmed the significant association of variations in CETP with longevity. The association of rs9923854 was borderline in the German population.
Indentifier

Study 8

Longevity Association: Significant
Population: Ashkenazi Jewish
Study Design: 205 centenarians (141 females, median age = 97 years and 64 males, median age = 97 years), their offspring (n = 145 total, 80 females, median age = 69 years and 65 males median age = 68 years), and 288 controls (167 females, median age = 74 years and 121 males, median age = 75 years) were examined for the association between genotype and longevity
Conclusions: A U-shape pattern of MTP CC genotype frequency with aging was observed. The CC was a buffered-deleterious genotype in the case group. In the control group without longevity genes, CC genotype included poorer survivorship.
Indentifier

Study 9

Longevity Association: Non-significant
Population: American of Japanese origin
Study Design: Total mortality, cause-specific mortality, and healthy survival were evaluated for associations with CETP genetic variants common in 3562 Japanese-American men from Honolulu Heart Program
Conclusions: No association was found between rs2303790 and mortality (p =.38). There was a trend for lower mortality for men with the Int 14A variant in rs5742907, though it failed to reach statistical significance.
Indentifier