LongevityMap Gene

Gene details

HGNC symbol: CELSR2
Aliases: EGFL2; MEGF3; ADGRC2; CDHF10; Flamingo1
Common name: cadherin EGF LAG seven-pass G-type receptor 2
Description: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 1p13.3
UCSC Genome Browser: View 1p13.3 on the UCSC genome browser
OMIM: 604265
Ensembl: ENSG00000143126
UniProt/Swiss-Prot: CELR2_HUMAN
Entrez Gene: 1952
UniGene: 57652
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: fmi-1
Danio rerio: celsr2
Drosophila melanogaster: stan
Mus musculus: Celsr2
Rattus norvegicus: Celsr2

Studies (1)

Significant/Non-significant: 0/1

Longevity Association

Non-significant

Population

Dutch

Study Design

A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls

Conclusions

No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.

Indentifier

rs646776

Reference