LongevityMap Gene

Gene details

HGNC symbol: CDKN2B-AS1
Aliases: ANRIL; p15AS; PCAT12; CDKN2BAS; CDKN2B-AS; NCRNA00089
Common name: CDKN2B antisense RNA 1
Description: This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]
Cytogenetic Location: 9p21.3
UCSC Genome Browser: View 9p21.3 on the UCSC genome browser
OMIM: 613149
Ensembl: ENSG00000240498
UniProt/Swiss-Prot
Entrez Gene: 100048912
UniGene: 493614
1000 Genomes: 1000 Genomes

No homologs found

Significant/Non-significant: 1/1

Longevity Association: Non-significant
Population: Dutch
Study Design: A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
Conclusions: No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
Indentifier

Longevity Association: Significant
Population: American (Caucasian)
Study Design: Genome-wide association study in 801 centenarians and 914 healthy controls
Conclusions: 281 SNPs were found to discriminate between cases and controls
Indentifier