LongevityMap Gene
Gene details
- HGNC symbol
- CDKAL1
- Aliases
- Common name
- CDK5 regulatory subunit associated protein 1 like 1
- Description
- The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010]
- Cytogenetic Location
- 6p22.3
- UCSC Genome Browser
- View 6p22.3 on the UCSC genome browser
- OMIM
- 611259
- Ensembl
- ENSG00000145996
- UniProt/Swiss-Prot
- CDKAL_HUMAN
- Entrez Gene
- 54901
- UniGene
- 657604
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- Y92H12BL.1
- Danio rerio
- cdkal1
- Drosophila melanogaster
- CG6550
- Mus musculus
- Cdkal1
- Rattus norvegicus
- Cdkal1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- A set of alleles associated with age-related diseases was tested for association with human longevity in 723 nonagenarian siblings and 721 unrelated younger controls plus 979 singleton individuals >85 years of age and 1,167 younger controls
- Conclusions
- No differences were observed in disease risk allele frequency between long-lived individuals and controls. No individual allele was significantly associated with survival to old age after controlling for multiple testing.
- Indentifier
- rs7754840
- Reference