LongevityMap Gene
Gene details
- HGNC symbol
- CCND1
- Aliases
- BCL1; PRAD1; U21B31; D11S287E
- Common name
- cyclin D1
- Description
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 11q13.3
- UCSC Genome Browser
- View 11q13.3 on the UCSC genome browser
- OMIM
- 168461
- Ensembl
- ENSG00000110092
- UniProt/Swiss-Prot
- CCND1_HUMAN
- Entrez Gene
- 595
- UniGene
- 523852
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- cyd-1
- Danio rerio
- ccnd1
- Drosophila melanogaster
- CycD
- Mus musculus
- Ccnd1
- Rattus norvegicus
- Ccnd1
- Saccharomyces cerevisiae
- CLB2
- Saccharomyces cerevisiae
- CLB5
- Saccharomyces cerevisiae
- CLB6
- Saccharomyces cerevisiae
- CLB4
- Saccharomyces cerevisiae
- CLB3
- Saccharomyces cerevisiae
- CLB1
In other databases
- GenAge model organism genes
- CellAge
- This gene is present as CCND1
- CellAge gene expression
- This gene is present as CCND1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Indentifier
- rs649392
- Reference