LongevityMap Gene
Gene details
- HGNC symbol
- CARS
- Aliases
- CARS1; CYSRS; MGC:11246
- Common name
- cysteinyl-tRNA synthetase
- Description
- This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
- Cytogenetic Location
- 11p15.4
- UCSC Genome Browser
- View 11p15.4 on the UCSC genome browser
- OMIM
- 123859
- Ensembl
- ENSG00000110619
- UniProt/Swiss-Prot
- A0A024RCG3_HUMAN
- Entrez Gene
- 833
- UniGene
- 274873
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- cars-1
- Danio rerio
- cars
- Drosophila melanogaster
- Aats-cys
- Mus musculus
- Cars
- Rattus norvegicus
- Cars
- Saccharomyces cerevisiae
- 855474
- Schizosaccharomyces pombe
- SPAC29E6.06c
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study using 1,471 genotyped participants from the Framingham Heart Study, of which 1,173 individuals had known lifespans, plus 517 individuals from the Offspring cohort for validating connections between longevity and genetic variants
- Conclusions
- A total of 27 SNPs, including in CDH4, SVEP1, CACNA1C, CARS, STK24, C7orf50, PARVG, NCAM2, PPP2R2C, NLRC5, BTBD9, RAC2, TGFA, KIAA0649, ABCC4, CLSTN2, FAM19A5 and RUNX3, were identified at the intersection of various statistical procedures
- Indentifier
- rs739401
- Reference