LongevityMap Gene
Gene details
- HGNC symbol
- CAMTA1
- Aliases
- CANPMR
- Common name
- calmodulin binding transcription activator 1
- Description
- The protein encoded by this gene contains a CG1 DNA-binding domain, a transcription factor immunoglobulin domain, ankyrin repeats, and calmodulin-binding IQ motifs. The encoded protein is thought to be a transcription factor and may be a tumor suppressor. However, a translocation event is sometimes observed between this gene and the WWTR1 gene, with the resulting WWTR1-CAMTA1 oncoprotein leading to epithelioid hemangioendothelioma, a malignant vascular cancer. [provided by RefSeq, Mar 2017]
- Cytogenetic Location
- 1p36.31-p36.23
- UCSC Genome Browser
- View 1p36.31-p36.23 on the UCSC genome browser
- OMIM
- 611501
- Ensembl
- ENSG00000171735
- UniProt/Swiss-Prot
- CMTA1_HUMAN
- Entrez Gene
- 23261
- UniGene
- 397705
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- camt-1
- Danio rerio
- camta1b
- Danio rerio
- camta1a
- Drosophila melanogaster
- Camta
- Mus musculus
- Camta1
- Rattus norvegicus
- Camta1
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs2032563
- Reference