LongevityMap Gene
Gene details
- HGNC symbol
- C9orf3
- Aliases
- APO; AP-O; AOPEP; ONPEP; C90RF3
- Common name
- chromosome 9 open reading frame 3
- Description
- This gene encodes a member of the M1 zinc aminopeptidase family. The encoded protein is a zinc-dependent metallopeptidase that catalyzes the removal of an amino acid from the amino terminus of a protein or peptide. This protein may play a role in the generation of angiotensin IV. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
- Cytogenetic Location
- 9q22.32
- UCSC Genome Browser
- View 9q22.32 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000148120
- UniProt/Swiss-Prot
- AMPO_HUMAN
- Entrez Gene
- 84909
- UniGene
- 434253
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Drosophila melanogaster
- CG10602
- Mus musculus
- 2010111I01Rik
- Rattus norvegicus
- Npepo
- Saccharomyces cerevisiae
- LAP2
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs1867102
- Reference