LongevityMap Gene
Gene details
- HGNC symbol
- C1orf167
- Aliases
- Common name
- chromosome 1 open reading frame 167
- Description
- Cytogenetic Location
- 1p36.22
- UCSC Genome Browser
- View 1p36.22 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000215910
- UniProt/Swiss-Prot
- A2VCK6_HUMAN
- Entrez Gene
- 284498
- UniGene
- 585415
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
No homologs found
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish, German, Dutch
- Study Design
- 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
- Conclusions
- After correcting for multiple testing, no SNPs were significantly associated with longevity, except in APOE and CETP. rs4343 (ACE) was nominally significantly associated with longevity (P < 0.05).
- Indentifier
- rs3737967
- Reference