LongevityMap Gene
Gene details
- HGNC symbol
- BRPF1
- Aliases
- BR140; IDDDFP
- Common name
- bromodomain and PHD finger containing 1
- Description
- This gene encodes a bromodomain, PHD finger and chromo/Tudor-related Pro-Trp-Trp-Pro (PWWP) domain containing protein. The encoded protein is a component of the MOZ/MORF histone acetyltransferase complexes which function as a transcriptional regulators. This protein binds to the catalytic MYST domains of the MOZ and MORF proteins and may play a role in stimulating acetyltransferase and transcriptional activity of the complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- Cytogenetic Location
- 3p25.3
- UCSC Genome Browser
- View 3p25.3 on the UCSC genome browser
- OMIM
- 602410
- Ensembl
- ENSG00000156983
- UniProt/Swiss-Prot
- BRPF1_HUMAN
- Entrez Gene
- 7862
- UniGene
- 1004
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- lin-49
- Danio rerio
- BRPF1
- Drosophila melanogaster
- Br140
- Mus musculus
- Brpf1
- Rattus norvegicus
- Brpf1
- Saccharomyces cerevisiae
- NTO1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs159153
- Reference