LongevityMap Gene
Gene details
- HGNC symbol
- ATP5J2-PTCD1
- Aliases
- Common name
- ATP5J2-PTCD1 readthrough
- Description
- This locus represents naturally occurring read-through transcription between the ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and PTCD1 (pentatricopeptide repeat domain 1) genes on chromosome 7. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]
- Cytogenetic Location
- 7q22.1
- UCSC Genome Browser
- View 7q22.1 on the UCSC genome browser
- OMIM
- Ensembl
- ENSG00000248919
- UniProt/Swiss-Prot
- B4DJ38_HUMAN
- Entrez Gene
- 100526740
- UniGene
- 632313
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Dutch
- Study Design
- Genome-wide association study in 403 unrelated nonagenarians from long-living families and 1670 younger controls. Strongest candidates were then investigated in a meta-analysis of 4149 nonagenarian cases and 7582 younger controls.
- Conclusions
- No SNP reached significance in the GWAS but 62 SNPs, many in genes, had an indicative association with survival into old age. Of these 62 SNPs then studied in the meta-analysis, 61 were not significant.
- Indentifier
- rs2003499
- Reference