LongevityMap Gene
Gene details
- HGNC symbol
- ART3
- Aliases
- ARTC3
- Common name
- ADP-ribosyltransferase 3
- Description
- This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- Cytogenetic Location
- 4q21.1
- UCSC Genome Browser
- View 4q21.1 on the UCSC genome browser
- OMIM
- 603086
- Ensembl
- ENSG00000156219
- UniProt/Swiss-Prot
- NAR3_HUMAN
- Entrez Gene
- 419
- UniGene
- 24976
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- art4
- Danio rerio
- si:ch73-379f5.5
- Danio rerio
- si:ch211-51i16.1
- Danio rerio
- CABZ01059912.1
- Danio rerio
- si:ch211-51i16.3
- Danio rerio
- BX908804.1
- Danio rerio
- si:ch211-163m16.7
- Danio rerio
- CABZ01019905.2
- Danio rerio
- CABZ01019905.1
- Danio rerio
- CABZ01059913.1
- Danio rerio
- CABZ01059914.1
- Danio rerio
- CR846080.1
- Mus musculus
- Art3
- Rattus norvegicus
- Art3
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Some signals were at best tentative but may merit study in larger sample sets
- Indentifier
- rs13111494
- Reference