LongevityMap Gene

Gene details

HGNC symbol: APOC3
Aliases: HALP2; APOCIII
Common name: apolipoprotein C3
Description: Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 11q23.3
UCSC Genome Browser: View 11q23.3 on the UCSC genome browser
OMIM: 107720
Ensembl: ENSG00000110245
UniProt/Swiss-Prot: A3KPE2_HUMAN
Entrez Gene: 345
UniGene: 73849
1000 Genomes: 1000 Genomes

Homologs in model organisms

Mus musculus: Apoc3
Rattus norvegicus: Apoc3

In other databases

GenAge human genes

This gene is present as APOC3

Studies (6)

Significant/Non-significant: 4/2

Study 1

Longevity Association

Population

Study Design

The Sst I polymorphism was examined in 179 Finnish centenarians

Conclusions

The S2 allele (Sst I restriction site present) occurred more often in the centenarians (frequency, 12.9%) than in the youngest reference population (frequency, 8.8%)

Indentifier

Reference

Study 2

Longevity Association

Population

Study Design

5'-untranslated region (T-455C) SNP was examined in a group of 137 elderly individuals (70-106 years old)

Conclusions

A greater frequency of the -455C allele was demonstrated with aging

Indentifier

Reference

Study 3

Longevity Association

Non-significant

Population

Italian (Southern)

Study Design

APOC3-SstI-RFLP polymorphism was examined in a healthy population of 304 subjects aged 18-45 years, 267 subjects aged 46-80 years and 229 subjects aged 81-109 years (including 184 subjects, 43 males and 141 females, older than 100 years)

Conclusions

No significant differences relative to longevity were found

Indentifier

APOC3-SstI-RFLP

Reference

Study 4

Longevity Association: Significant
Population: Ashkenazi Jewish
Study Design: A group of centenarians (213), their offspring (216), and an age-matched control group (258) were genotyped for 66 polymorphisms in 36 candidate genes related to cardiovascular disease
Conclusions: The prevalence of homozygosity for the 641C allele in the APOC3 promoter (rs2542052) was higher in centenarians (25%) and their offspring (20%) than in controls (10%). This genotype was associated with significantly lower serum levels of APOC3, a favorable pattern of lipoprotein levels and sizes. A lower prevalence of hypertension and greater insulin sensitivity in the 641C homozygotes was also found.
Indentifier

Study 5

Longevity Association: Non-significant
Population: Danish, German, Dutch
Study Design: 102 SNPs from 16 longevity candidate genes were examined in Danish. 1089 individuals (ages 92.2-93.8, mean age 93.2, 71.3 female) and 736 middle-aged controls (46-55 y, mean age 50.6, 49.6% female) were involved in this case-control study. Then the results were replicated in a German cohort of 1613 individuals (95-110 y, 73.2% female) and 1104 middle-aged controls (mean age 67.2, SD 4.07, 74.3% female). A 11 years study was introduced in Danish cohort to identify the SNPs associated with longevity, then the results were verified in Dutch longitudinal cohort.
Conclusions: After correcting for multiple testing, no SNPs were significantly associated with longevity, except in APOE and CETP. rs4343 (ACE) was nominally significantly associated with longevity (P < 0.05).
Indentifier

Study 6

Longevity Association: Significant
Population: Ashkenazi Jewish
Study Design: 205 centenarians (141 females, median age = 97 years and 64 males, median age = 97 years), their offspring (n = 145 total, 80 females, median age = 69 years and 65 males median age = 68 years), and 288 controls (167 females, median age = 74 years and 121 males, median age = 75 years) were examined for the association between genotype and longevity
Conclusions: A U-shape pattern of MTP CC genotype frequency with aging was observed. The CC was a buffered-deleterious genotype in the case group. In the control group without longevity genes, CC genotype included poorer survivorship.
Indentifier