LongevityMap Gene
Gene details
- HGNC symbol
- APBB2
- Aliases
- FE65L; FE65L1
- Common name
- amyloid beta precursor protein binding family B member 2
- Description
- The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
- Cytogenetic Location
- 4p14-p13
- UCSC Genome Browser
- View 4p14-p13 on the UCSC genome browser
- OMIM
- 602710
- Ensembl
- ENSG00000163697
- UniProt/Swiss-Prot
- APBB2_HUMAN
- Entrez Gene
- 323
- UniGene
- 479602
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- feh-1
- Danio rerio
- apbb2b
- Danio rerio
- CABZ01085924.1
- Mus musculus
- Apbb2
- Rattus norvegicus
- Apbb2
Studies (1)
Significant/Non-significant: 1/0
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study in 801 centenarians and 914 healthy controls
- Conclusions
- 281 SNPs were found to discriminate between cases and controls
- Indentifier
- rs765850
- Reference