LongevityMap Gene

Gene details

HGNC symbol: ADAMTSL1
Aliases: C9orf94; PUNCTIN; ADAMTSR1; ADAMTSL-1
Common name: ADAMTS like 1
Description: This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 9p22.2-p22.1
UCSC Genome Browser: View 9p22.2-p22.1 on the UCSC genome browser
OMIM: 609198
Ensembl: ENSG00000178031
UniProt/Swiss-Prot: ATL1_HUMAN
Entrez Gene: 92949
UniGene: 741483
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: madd-4
Drosophila melanogaster: CG31619
Mus musculus: Adamtsl1
Rattus norvegicus: Adamtsl1

Studies (1)

Significant/Non-significant: 1/0

Longevity Association

Significant

Population

American (Caucasian)

Study Design

Genome-wide association study in 801 centenarians and 914 healthy controls

Conclusions

281 SNPs were found to discriminate between cases and controls

Indentifier

Reference