LongevityMap Gene
Gene details
- HGNC symbol
- ACOX1
- Aliases
- ACOX; SCOX; PALMCOX
- Common name
- acyl-CoA oxidase 1
- Description
- The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 17q25.1
- UCSC Genome Browser
- View 17q25.1 on the UCSC genome browser
- OMIM
- 609751
- Ensembl
- ENSG00000161533
- UniProt/Swiss-Prot
- ACOX1_HUMAN
- Entrez Gene
- 51
- UniGene
- 464137
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- F08A8.4
- Caenorhabditis elegans
- acox-5
- Caenorhabditis elegans
- F59F4.1
- Caenorhabditis elegans
- acox-3
- Caenorhabditis elegans
- acox-2
- Caenorhabditis elegans
- acox-1
- Danio rerio
- acox1
- Drosophila melanogaster
- CG4586
- Drosophila melanogaster
- CG5009
- Drosophila melanogaster
- Acox57D-p
- Drosophila melanogaster
- Acox57D-d
- Mus musculus
- Acox1
- Rattus norvegicus
- Acox1
- Saccharomyces cerevisiae
- POX1
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Indentifier
- rs1137582
- Reference