LongevityMap Gene
Gene details
- HGNC symbol
- ABCA7
- Aliases
- AD9; ABCX; ABCA-SSN
- Common name
- ATP binding cassette subfamily A member 7
- Description
- The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 19p13.3
- UCSC Genome Browser
- View 19p13.3 on the UCSC genome browser
- OMIM
- 605414
- Ensembl
- ENSG00000064687
- UniProt/Swiss-Prot
- ABCA7_HUMAN
- Entrez Gene
- 10347
- UniGene
- 134514
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- abt-2
- Danio rerio
- zgc:172302
- Mus musculus
- Abca7
- Rattus norvegicus
- Abca7
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- American, English, Irish
- Study Design
- 10 late-onset Alzheimer's disease genes were tested for association with human aging in the dataset (1385 samples with documented age at death, age range: 58–108 years; mean age at death: 80.2 years) using the most significant SNPs found in the previous studies. A set of 41 tentative SNPs span the genome were identified in this study.
- Conclusions
- Apart APOE, no variants appeared to be associated with aging with a genome-wide level of significance
- Indentifier
- rs3764650
- Reference