LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- Ashkenazi Jewish
- Study Design
- A comprehensive resequencing of SIRT1 gene in 16 centenarians and 16 controls identified 36 SNPs (5 of those were novel SNPs). 19 SNPs with MAF > 0.05 were tested in 312 centenarians and 169 controls for association with longevity. 5 tagSNPs from a total 19 SNPs were tested for association with lipid profiles.
- Conclusions
- No association was found between SIRT1 SNPs and longevity, although rs10997854 and rs142194353 were associated with lipid parameters.
Variants (19)
1.
- Identifier
- rs10997857
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
2.
- Identifier
- rs3740053
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
3.
- Identifier
- rs932658
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
4.
- Identifier
- rs3740051
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
5.
- Identifier
- rs35706870
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
6.
- Identifier
- rs3758391
- In Other Studies (IDs)
- 1478 2038
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
7.
- Identifier
- rs12778366
- In Other Studies (IDs)
- 379 1468
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
8.
- Identifier
- rs148743102
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
9.
- Identifier
- rs12250285
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
10.
- Identifier
- rs10823102
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
11.
- Identifier
- rs2394443
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
12.
- Identifier
- rs10823101
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
13.
- Identifier
- rs10997856
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
14.
- Identifier
- rs10823100
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
15.
- Identifier
- rs142194353
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
16.
- Identifier
- rs10997855
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
17.
- Identifier
- rs10997854
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
18.
- Identifier
- rs2273773
- In Other Studies (IDs)
- 1473 2123
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
19.
- Identifier
- rs7896005
- In Other Studies (IDs)
- 251
- Cytogenetic Location
- 10q21.3
- UCSC Genome Browser
- View 10q21.3 on the UCSC genome browser
Gene details
- HGNC symbol
- SIRT1
- Aliases
- SIR2; SIR2L1; SIR2alpha
- Common name
- sirtuin 1
- Description
- This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
- Other longevity studies of this gene
- 33
- OMIM
- 604479
- Ensembl
- ENSG00000096717
- UniProt/Swiss-Prot
- A0A024QZQ1_HUMAN
- Entrez Gene
- 23411
- UniGene
- 369779
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sir-2.1
- Danio rerio
- sirt1
- Drosophila melanogaster
- Sir2
- Mus musculus
- Sirt1
- Rattus norvegicus
- Sirt1
- Saccharomyces cerevisiae
- HST1
- Saccharomyces cerevisiae
- SIR2
In other databases
- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- A homolog of this gene for Drosophila melanogaster is present as Sir2
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Mus musculus is present as Sirt1
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- GenAge human genes
- This gene is present as SIRT1
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as Sir2
- A homolog of this gene for Mus musculus is present as Sirt1
- A homolog of this gene for Caenorhabditis elegans is present as sir-2.1
- A homolog of this gene for Saccharomyces cerevisiae is present as SIR2
- A homolog of this gene for Saccharomyces cerevisiae is present as HST1
- CellAge
- This gene is present as SIRT1