LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Korean
- Study Design
- 463 biomarkers in 176 diesase associated genes were examined in 137 long lived individuals (>90 y, 59.1% female, 96.73 ± 3.97 y) and 213 young controls (12-14 y, 39.4% female, 12.93 ± 0.80)
- Conclusions
- EGFR was associated with longevity (P = 0.003) after correcting for multiple hypothesis testing
Variants (4)
1.
- Identifier
- rs2072454
- Cytogenetic Location
- 7p11.2
- UCSC Genome Browser
- View 7p11.2 on the UCSC genome browser
2.
- Identifier
- rs2293347
- Cytogenetic Location
- 7p11.2
- UCSC Genome Browser
- View 7p11.2 on the UCSC genome browser
3.
- Identifier
- rs3807362
- Cytogenetic Location
- 7p11.2
- UCSC Genome Browser
- View 7p11.2 on the UCSC genome browser
4.
- Identifier
- rs884225
- Cytogenetic Location
- 7p11.2
- UCSC Genome Browser
- View 7p11.2 on the UCSC genome browser
Gene details
- HGNC symbol
- EGFR
- Aliases
- ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
- Common name
- epidermal growth factor receptor
- Description
- The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016]
- Other longevity studies of this gene
- 3
- OMIM
- 131550
- Ensembl
- ENSG00000146648
- UniProt/Swiss-Prot
- B7Z2I3_HUMAN
- Entrez Gene
- 1956
- UniGene
- 488293
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as EGFR