LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Genotyping of 56 single nucleotide polymorphisms located in the CYP2C gene family was performed for 1384 unrelated long-lived individuals (age range: 95-109 years, mean: 98.8 years), including 616 centenarians (mean age: 101.3 years), and 945 younger controls (age range: 60-75 years, mean: 66.9 years). The gender ratio was 73% females versus 27% males.
- Conclusions
- None of the tested single nucleotide polymorphisms showed a significant association with the longevity phenotype at the allele, genotype, or haplotype level
Variants (56)
- Gene summary:
- No gene (1)
- CYP2C18 (10)
- CYP2C19 (11)
- CYP2C58P (1)
- CYP2C8 (13)
- CYP2C9 (20)
No gene
CYP2C18
Gene details
- HGNC symbol
- CYP2C18
- Aliases
- CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C
- Common name
- cytochrome P450 family 2 subfamily C member 18
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 9
- OMIM
- 601131
- Ensembl
- ENSG00000108242
- UniProt/Swiss-Prot
- CP2CI_HUMAN
- Entrez Gene
- 1562
- UniGene
- 511872
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
CYP2C19
Gene details
- HGNC symbol
- CYP2C19
- Aliases
- CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19
- Common name
- cytochrome P450 family 2 subfamily C member 19
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 10
- OMIM
- 124020
- Ensembl
- ENSG00000165841
- UniProt/Swiss-Prot
- CP2CJ_HUMAN
- Entrez Gene
- 1557
- UniGene
- 282409
- HapMap
- View on HapMap
Homologs in model organisms
CYP2C58P
Gene details
- HGNC symbol
- CYP2C58P
- Aliases
- Common name
- cytochrome P450 family 2 subfamily C member 58, pseudogene
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 106480430
- UniGene
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
CYP2C8
Gene details
- HGNC symbol
- CYP2C8
- Aliases
- CPC8; CYPIIC8; MP-12/MP-20
- Common name
- cytochrome P450 family 2 subfamily C member 8
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
- Other longevity studies of this gene
- 12
- OMIM
- 601129
- Ensembl
- ENSG00000138115
- UniProt/Swiss-Prot
- B7Z1F5_HUMAN
- Entrez Gene
- 1558
- UniGene
- 709188
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
CYP2C9
Gene details
- HGNC symbol
- CYP2C9
- Aliases
- CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
- Common name
- cytochrome P450 family 2 subfamily C member 9
- Description
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 19
- OMIM
- 601130
- Ensembl
- ENSG00000138109
- UniProt/Swiss-Prot
- CP2C9_HUMAN
- Entrez Gene
- 1559
- UniGene
- 282624
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found