LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Ashkenazi Jewish
- Study Design
- TSH heritability, its distribution, and association with SNPs in the TSH-B and TSHR genes was determined in Ashkenazi Jewish centenarians (n = 232; median age, 97 yr), their offspring (n = 366; median age, 69 yr), and age-matched controls without familial longevity (n = 163; median age, 70 yr)
- Conclusions
- A heritable phenotype characterized by raised serum TSH is associated with human longevity. Allele frequency of two SNPs in the promoter/enhancer region of TSHR gene (rs12050077 and rs10149689), associated with increased serum TSH, was higher in centenarians and their offspring compared to controls.
Variants (2)
1.
- Identifier
- rs12050077
- Cytogenetic Location
- 14q31.1
- UCSC Genome Browser
- View 14q31.1 on the UCSC genome browser
2.
- Identifier
- rs10149689
- Cytogenetic Location
- 14q31.1
- UCSC Genome Browser
- View 14q31.1 on the UCSC genome browser
Gene details
- HGNC symbol
- CEP128
- Aliases
- C14orf61; LEDP/132; C14orf145
- Common name
- centrosomal protein 128
- Description
- Other longevity studies of this gene
- 1
- OMIM
- Ensembl
- ENSG00000100629
- UniProt/Swiss-Prot
- CE128_HUMAN
- Entrez Gene
- 145508
- UniGene
- 162889
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- CellAge gene expression
- This gene is present as CEP128