LongevityMap variant group
Entry Details
- Longevity Association
- Significant
- Population
- Chinese (Han)
- Study Design
- Six tagging SNPs from FOXO1A and FOXO3A were selected and genotyped in 1817 centenarians and younger individuals
- Conclusions
- Two SNPs of FOXO1A were found to be associated with longevity in women (P = 0.01-0.005)
Variants (2)
1.
2.
- Identifier
- rs2755213
- In Other Studies (IDs)
- 593 1582 1673
- Cytogenetic Location
- 13q14.11
- UCSC Genome Browser
- View 13q14.11 on the UCSC genome browser
Gene details
- HGNC symbol
- FOXO1
- Aliases
- FKH1; FKHR; FOXO1A
- Common name
- forkhead box O1
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 30
- OMIM
- 136533
- Ensembl
- ENSG00000150907
- UniProt/Swiss-Prot
- FOXO1_HUMAN
- Entrez Gene
- 2308
- UniGene
- 370666
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo1a
- Danio rerio
- foxo1b
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo1
- Rattus norvegicus
- Foxo1
- Saccharomyces cerevisiae
- HCM1