LongevityMap variant group

Entry Details

Longevity Association: Non-significant
Population: Bulgarian
Study Design: -1082G/A, -819 C/T and -592 C/A SNPs were examined in 17 unrelated elderly (age 65-90 years; 6 males and 11 females), 23 family members (age 18-57 years; 9 males and 14 females, and a control group with 105 randomly selected, matched for geographical dist
Conclusions: Genotype -1082G/A, -819 C/C, -592 C/C was positively associated, while genotype -1082A/A, -819 C/T, -592 C/A, was negatively associated with longevity in Bulgarians. The results, however, were not statistically significant.

HGNC symbol: IL10
Aliases: CSIF; TGIF; GVHDS; IL-10; IL10A
Common name: interleukin 10
Description: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Other longevity studies of this gene: 15
OMIM: 124092
Ensembl: ENSG00000136634
UniProt/Swiss-Prot: IL10_HUMAN
Entrez Gene: 3586
UniGene: 193717
HapMap: View on HapMap