LongevityMap variant group

Entry Details

Longevity Association: Non-significant
Population: French
Study Design: NAT25A (C481T), NAT26A (G590A), NAT27A (G857A), and NAT214A (G191A) SNPs were examined in 552 centenarians and 243 controls aged 20-70 years
Conclusions: No significant difference was found between centenarian and control subjects with respect to allelic variant frequencies, genotype distributions or predicted phenotypes deduced from genotype combinations

HGNC symbol: NAT2
Aliases: AAC2; PNAT; NAT-2
Common name: N-acetyltransferase 2
Description: This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 6
OMIM: 612182
Ensembl: ENSG00000156006
UniProt/Swiss-Prot: A4Z6T7_HUMAN
Entrez Gene: 10
UniGene: 2
HapMap: View on HapMap