LongevityMap variant
- Longevity Association
- Significant
- Population
- European
- Study Design
- A genome-wide association meta-analysis was performed in 7729 long-lived individuals of European descent (>=85 years) and 16,121 younger controls ( <65 years) followed by replication in an additional set of 13,060 long-lived individuals and 61 156 controls.
- Conclusions
- rs2149954 and rs4420638 were observed significantly associated with longevity. Meta-analysis showed rs2149954 (T) associates with increased survival.
- HGNC symbol
- APOC1
- Aliases
- Apo-CI; ApoC-I; apo-CIB; apoC-IB
- Common name
- apolipoprotein C1
- Description
- This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]
- Other longevity studies of this gene
- 3
- OMIM
- 107710
- Ensembl
- ENSG00000130208
- UniProt/Swiss-Prot
- A0A024R0T8_HUMAN
- Entrez Gene
- 341
- UniGene
- 110675
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Apoc1
- Rattus norvegicus
- Apoc1
- Rattus norvegicus
- LOC100910181
- Rattus norvegicus
- Apoc1
- Rattus norvegicus
- Apoc1
- CellAge gene expression
- This gene is present as APOC1
Deelen et al. (2014)
Other variants which are also part of this study