LongevityMap variant
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- Intron 4 A/T SNP was examined in 1576 individuals aged 85 and older
- Conclusions
- Female carriers of the A allele had reduced height and mortality
- HGNC symbol
- GH1
- Aliases
- GH; GHN; GH-N; GHB5; hGH-N; IGHD1B
- Common name
- growth hormone 1
- Description
- The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 1
- OMIM
- 139250
- Ensembl
- ENSG00000259384
- UniProt/Swiss-Prot
- B1A4G6_HUMAN
- Entrez Gene
- 2688
- UniGene
- 655229
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- gh1
- Mus musculus
- Gh
- Rattus norvegicus
- Gh1
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Gh
- GenAge human genes
- This gene is present as GH1
van Heemst et al. (2005)
Other variants which are also part of this study