LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Japanese
- Study Design
- PvuII and HindIII polymorphisms were examined in 256 centenarians and 190 healthy younger controls (22-65 years old)
- Conclusions
- The allelic frequencies were not different between the two groups
- HGNC symbol
- LPL
- Aliases
- LIPD; HDLCQ11
- Common name
- lipoprotein lipase
- Description
- LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]
- OMIM
- 609708
- Ensembl
- ENSG00000175445
- UniProt/Swiss-Prot
- A0A1B1RVA9_HUMAN
- Entrez Gene
- 4023
- UniGene
- 180878
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- LPL (1 of many)
- Danio rerio
- lpl
- Drosophila melanogaster
- CG1986
- Mus musculus
- Lpl
- Rattus norvegicus
- Lpl
Arai et al. (2003)
Other variants which are also part of this study