LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: APOA4-HincII-RFLP (Asp127/Ser127) polymorphism was examined in a healthy population with 304 subjects aged 18-45 years, 267 subjects aged 46-80 years and 229 subjects aged 81-109 years (including 184 subjects, 43 males and 141 females, older than 100 years)
Conclusions: No significant differences relative to longevity were found

HGNC symbol: APOA4
Aliases
Common name: apolipoprotein A4
Description: Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 2
OMIM: 107690
Ensembl: ENSG00000110244
UniProt/Swiss-Prot
Entrez Gene: 337
UniGene: 1247
HapMap: View on HapMap

Garasto et al. (2003)