LongevityMap variant
- Longevity Association
- Significant
- Population
- Dutch
- Study Design
- Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls
- Conclusions
- SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity
- HGNC symbol
- SGK1
- Aliases
- SGK
- Common name
- serum/glucocorticoid regulated kinase 1
- Description
- This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
- Other longevity studies of this gene
- 1
- OMIM
- 602958
- Ensembl
- ENSG00000118515
- UniProt/Swiss-Prot
- B7Z325_HUMAN
- Entrez Gene
- 6446
- UniGene
- 510078
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sgk-1
- Danio rerio
- sgk1
- Mus musculus
- Sgk1
- Rattus norvegicus
- Sgk1
- Saccharomyces cerevisiae
- SCH9
- Saccharomyces cerevisiae
- YPK1
- Saccharomyces cerevisiae
- YPK2
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
- A homolog of this gene for Caenorhabditis elegans is present as sgk-1
- A homolog of this gene for Saccharomyces cerevisiae is present as YPK1
- GenAge microarray genes
- This gene is present as SGK1
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as SCH9
- CellAge
- This gene is present as SGK1
Deelen et al. (2013)
Other variants which are also part of this study
