LongevityMap variant
- Longevity Association
- Significant
- Population
- Italian
- Study Design
- The -1082G/A, -819C/T and -592C/A proximal promoter SNPs were examined in 190 centenarians (>99 years old, 159 women and 31 men) and in 260 control subjects (99 women and 161 men less than 60 years old)
- Conclusions
- The -1082G homozygous genotype, associated with high IL-10 production, was increased in centenarian men but not in centenarian women. No difference was found between centenarians and control subjects regarding the other two SNPs.
- HGNC symbol
- IL10
- Aliases
- CSIF; TGIF; GVHDS; IL-10; IL10A
- Common name
- interleukin 10
- Description
- The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
- Other longevity studies of this gene
- 15
- OMIM
- 124092
- Ensembl
- ENSG00000136634
- UniProt/Swiss-Prot
- IL10_HUMAN
- Entrez Gene
- 3586
- UniGene
- 193717
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- il10
- Mus musculus
- Il10
- Rattus norvegicus
- Il10
Lio et al. (2002)
Other variants which are also part of this study
