LongevityMap variant
- Longevity Association
- Significant
- Population
- Italian
- Study Design
- The distribution of the 874T/A polymorphism was examined in 174 Italian centenarians (>99 years old, 142 women and 32 men) and 248 <60-year-old control subjects (90 women and 158 men)
- Conclusions
- The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls.
- HGNC symbol
- IFNG
- Aliases
- IFG; IFI
- Common name
- interferon gamma
- Description
- This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
- Other longevity studies of this gene
- 5
- OMIM
- 147570
- Ensembl
- ENSG00000111537
- UniProt/Swiss-Prot
- IFNG_HUMAN
- Entrez Gene
- 3458
- UniGene
- 856
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Ifng
- Rattus norvegicus
- Ifng
- CellAge
- This gene is present as IFNG
Lio et al. (2002)
Other variants which are also part of this study