LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- FokI RFLP polymorphism was examined in 219 centenarians (72 males and 147 females) and 256 (controls 20-70 years, 119 males and 137 females)
- Conclusions
- No significant difference between centenarians and controls was observed
- HGNC symbol
- INS
- Aliases
- IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
- Common name
- insulin
- Description
- After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
- Other longevity studies of this gene
- 5
- OMIM
- 176730
- Ensembl
- ENSG00000254647
- UniProt/Swiss-Prot
- I3WAC9_HUMAN
- Entrez Gene
- 3630
- UniGene
- 272259
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- ins
- Danio rerio
- insb
- Mus musculus
- Ins2
- Mus musculus
- Ins1
- Rattus norvegicus
- Ins1
- Rattus norvegicus
- Ins2
- GenAge human genes
- This gene is present as INS
De Luca et al. (2001)
Other variants which are also part of this study