LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Finnish
- Study Design
- 250 (52 males and 198 females) nonagenarians and 400 healthy control group (18-60 years old) were examined for -889 SNP
- Conclusions
- No significant differences relative to longevity were found
- HGNC symbol
- IL1A
- Aliases
- IL1; IL-1A; IL1F1; IL1-ALPHA
- Common name
- interleukin 1 alpha
- Description
- The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 4
- OMIM
- 147760
- Ensembl
- ENSG00000115008
- UniProt/Swiss-Prot
- IL1A_HUMAN
- Entrez Gene
- 3552
- UniGene
- 1722
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Il1a
- Rattus norvegicus
- Il1a
- CellAge
- This gene is present as IL1A
Wang et al. (2001)
Other variants which are also part of this study
