LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Finnish
Study Design: 250 (52 males and 198 females) nonagenarians and 400 healthy control group (18-60 years old) were examined for 1082 SNP
Conclusions: No significant differences relative to longevity were found

HGNC symbol: IL10
Aliases: CSIF; TGIF; GVHDS; IL-10; IL10A
Common name: interleukin 10
Description: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Other longevity studies of this gene: 15
OMIM: 124092
Ensembl: ENSG00000136634
UniProt/Swiss-Prot: IL10_HUMAN
Entrez Gene: 3586
UniGene: 193717
HapMap: View on HapMap